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The Natural Estrogen Diet and Recipe Book: Delicious Recipes for a Healthy Lifestyle St. Simons Trilogy but focus on one gameThe National Institute of Health interrupted their huge HRT study in July 2002 when they found that the drug Prempro, a combination of estrogen and progestin, had detrimental health effects. The women who took the drug exhibited an increased risk for breast cancer, heart disease, and stroke. Women can lose up to 20% of their bone mass in the first seven years after menopause. Post menopausal women are twice as likely as men to die of a heart attack.